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Revolutionize your skin with our cream: tretinoin, azelaic acid, and niacinamide work together to clear acne and rosacea.

Tretinoin / Azelaic Acid / Niacinamide Cream is a hypoallergenic cream that is a combination of prescription drug products that has been designed to treat rosacea and acne vulgaris. Although over-the-counter treatments may be effective for mild cases of acne, more persistent cases necessitate more potent treatments. Additionally, it is challenging to identify a single product that is effective in the treatment of both acne vulgaris and rosacea. Combining tretinoin, azelaic acid, and niacinamide into a single formulation has the potential to enhance both conditions and increase patient compliance with treatment. The preparation is applied to the affected area once to twice daily, and the ingredients work in a synergistic manner to reduce redness and pimples. The compound may also provide additional advantages, such as the reduction of hyperpigmentation and the reduction of fine lines and wrinkles.

Tretinoin

Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (or retinol) that enhances cell turnover. Tretinoin is administered as a topical treatment for mild to moderate acne (e.g., grades I-III), photodamaged skin, and keratinisation disorders, including ichthyosis and keratosis follicularis. Topical tretinoin is effective in the reduction of fine lines, hyperpigmentation, roughness, and laxity that are indicative of photodamaged skin. By expediting the process of cell renewal, it eliminates discolourations and blemishes from the skin.

Azelaic acid

Azelaic acid is a naturally occurring substance that is present in wheat, rye, and barley. It is also naturally produced by a specific fungus that is present on human skin. Azelaic acid is applied topically to treat rosacea, acne vulgaris, and other inflammatory skin conditions. It has been demonstrated to be significantly more effective than metronidazole in alleviating rosacea symptoms. It is believed that it functions by preventing the growth of aerobic and anaerobic bacteria and eliminating them, although the mechanism of action is not entirely clarified. Nevertheless, mild to moderate itching and dry skin are potential side effects of azelaic acid when applied topically. It is generally well-tolerated.

Niacinamide

Niacinamide is the physiologically active form of niacin (vitamin B3). Niacinamide is a precursor of the cofactors niacinamide adenine dinucleotide (NAD) and niacinamide adenine dinucleotide phosphate (NADP), which are naturally present in food (e.g., meat, dairy products, legumes, nuts, seeds, green leafy vegetables, fortified grains, etc.). NAD and NADP are critical components of numerous essential metabolic pathways in the human body. Niacinamide is applied topically to alleviate a variety of skin conditions, such as acne vulgaris, bullous pemphigoid, IgA bullous dermatosis, and pruritus (itching), due to its powerful anti-inflammatory properties. Research has also demonstrated that niacinamide has the capacity to diminish hyperpigmentation and redness when applied topically.